Hycult Biotech

A-FABP, Mouse, Recombinant (E-Coli-derived)

Product Description

  • Adipocyte Fatty Acid Binding Protein (A-FABP), also known as FABP4, aP2 and ALBP, is a 15 kDa protein and is one of the most abundant proteins in mature adipocytes. Human and mouse A-FABP share 91% amino acid sequence homology. Several adipokines from adipose tissues have been identified. The y mediate the cross talk between adipose tissue and the cardiovascular system. This interaction between adipose tissue, macrophages and several inflammatory cells leads to expression of, besides A-FABP, among others TNF-α, IL-6, MCP-1, leptin, lipocalin-2 and Pai-1. A-FABP is expressed in macrophages and lymphocytes. A-FABP plays a role in the intracellular utilization of fatty acids, transport and metabolism. The putative function of A-FABP is to serve as a lipid-binding chaperone for fatty acids. The protein was identified as a cytoplasmic protein, but is also described to be secreted by adipose tissue in the bloodstream. A-FABP have closely been associated with metabolic syndrome, obesity and atherosclerosis. It is considered as a therapeutic target for these processes in animal models. Several groups have demonstrated an association between serum levels of A-FABP and obesity-related cardiometabolic risk factors, endothelial dysfunction and macrovascular complications of diabetes. The proatherogenic activity of A-FABP is mediated by its direct actions on macrophages, independently of lipid metabolism and insulin sensitivity. In line with clinical findings, data from animal studies also supports a role of A-FABP in cardiovascular disease. HC1104 recombinant protein has been isolated from bacteria using affinity purification.

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Product Number Description Package Size List Price (CAD)
HYBHC1104 A-FABP, Mouse, Recombinant (E-Coli-derived) 50 µg
CA$451.00
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