Mononucleosomes (H2AX), Human Recombinant Biotinylated
- Supplier: EpiCypher
- Storage Conditions: Stable for 6 months at -80°C from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.
- Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2AX, H2B, H3 and H4. Accession numbers: H2AX-P16104; H2B-O60814; H3.1-P68431; H4-P62805) wrapped by 147 base pairs of 601 positioning sequence DNA with a 5Õ biotin-TEG group. The nucleosome is the basic subunit of chromatin. H2AX is a variant of histone H2A that is phosphorylated on serine 139 by the ATM and ATR kinases in response to DNA double strand breakage. Phosphorylation of H2AX serves to recruit a number of DNA damage repair proteins, such as BRCA1 and NBS1.
|Product Number||Description||Package Size||List Price (CAD)|
|EP160013||Mononucleosomes (H2AX), Human Recombinant Biotinylated||50 µg||
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