dCypher™ Nucleosome Full Panel
- Supplier: EpiCypher
- Storage Conditions: Stable for 6 months at -80°C from date of receipt. Avoid multiple freeze/thaws.
Product Description
- Understanding epigenetic reader proteins and their binding preference for post-translational modifications (PTMs) is key to unveiling how these proteins regulate genome processes and how their dysregulation may be contributing to disease. The dCypher™ Nucleosome Panel enables access to epigenetic diversity in a physiologically relevant context, the nucleosome, where chromatin reader activity can be accurately interrogated. The 96-well plate contains recombinant mononucleosomes as well as appropriate controls. Human histones expressed in E. coli bearing single and combinatorial histone post-translational modifications (PTMs) are wrapped by 147 or 199 base pair DNA with a 5’ biotin-TEG group and a central 601-positioning sequence.
- All nucleosomes in the panel are subjected to EpiCypher’s rigorous quality control metrics, including: ESI-TOF mass spectrometry analysis of the modified histones, SDS-PAGE to confirm octamer composition and purity, native PAGE to confirm nucleosome assembly, and western blot analysis of the PTM, histone mutation, or histone variant (if applicable).
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Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| EP169001 | dCypher™ Nucleosome Full Panel | 96 well plate |
CA$2,677.00
|
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