Pentraxin 3, Human, ELISA Kit
- Supplier: Hycult Biotech
Product Description
- Pentraxins are a superfamily of acute phase reactants charactarized by a pentameric_x000D_ structure. The C-reactive protein (CRP) and serum amyloid P-component (SAP) are well charactarized short Pentraxins, which are produced in the liver in response to inflammatory_x000D_
- mediators. Pentraxin 3 (PTX3), also known as Tumor necrosis factor-Stimulated Gene 14_x000D_ (TSG-14), is the prototypic long Pentraxin, with a high degree of conservation from mouse to_x000D_ man._x000D_
- Human PTX3 encodes a 45 kDa secretory glycoprotein with a 162 amino acid N-terminal_x000D_ extension and a 202 amino acid C-terminal Pentraxin domain. The protein is locally produced_x000D_ and released by a variety of cell types including macrophages, neutrophils, myeloid-derived_x000D_ mesangial cells, synovial cells, smooth muscle cells, alveolar epithelium, and glial cells._x000D_ PTX3 is induced in response to either inflammatory cytokines interleukin-1 β (IL-1 β) and_x000D_ tumor necrosis factor α (TNFα) or the selected associated molecular patterns (PAMPs)._x000D_ PTX3 has a dual role in the regulation of the innate immune response. Via its C-terminal_x000D_ Pentraxin domain, immobilized PTX3 will bind complement component C1q to induce_x000D_ classical complement activation. However, fluid-phase PTX3 inhibits classical complement_x000D_ activation. Furthermore PTX3 participates in the clearance of apoptic cells._x000D_ PTX3 is elevated in critically ill patients, with a gradient from systematic inflammatory_x000D_ resonse syndrome to septic shock, and in several other diseases, such as mycocardial_x000D_ infarction, rheumatoid arthritis, atherosclerosis, small vessel vasculitis and psoriasis._x000D_ Furthermore serum levels of PTX3 are higher in preeclamsia compared with normal_x000D_ pregancies.
- The human pentraxin 3 ELISA has been developed for the quantitative measurement of natural and recombinant human pentraxin 3 in plasma and cell culture medium.
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHK34701 | Pentraxin 3, Human, ELISA kit | 1 x 96 det. |
CA$1,285.00
|
Add to Cart | |
| HYBHK34702 | Pentraxin 3, Human, ELISA kit | 2 x 96 det. |
CA$2,020.00
|
Add to Cart |
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