Hycult Biotech

TNF-RII, Mouse, Monoclonal Antibody HM102

Product Description

  • The monoclonal antibody HM102 recognizes the extracellular part of membrane-bound TNF-RII as well as the soluble form of TNF-RII which is generated by proteolytic cleavage of the extracellular domain. The soluble form can still bind TNF-alpha with high affinity and functions as a TNF-alpha antagonist. TNF-alpha is an important signalling protein in the immune system which can activate inflammatory responses, induce apoptosis, regulate cellular proliferation, and may even promote cancer progression. TNF-alpha can bind to two structurally distinct membrane receptors, TNF-RI and TNFRII, which have both distinct and overlapping downstream signaling cascades. TNFRI is believed to be expressed on nearly all cell types, whereas TNFRII exhibits more restricted expression, being found on certain subpopulations of immune cells and several other cell types. A dominant role of TNFRII has been shown in thymocyte activation by TNF-alpha, whereas induction of cytotoxicity and other functions are mediated largely by TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is activated only by the membrane bound form of TNF-alpha. The antibody is a agonistic receptor modulating antibody. It enhances in vitro TNF alpha responses by increasing the affinity of the soluble form of TNF-alpha for TNF-RII.
  • Applications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Immunoprecipitation , Western Blot

Resources

Product Options

Product Number Description Package Size List Price (CAD)
HYBHM101120UG TNF-RII, Mouse, mAb HM102, 20 µg 20 µg
CA$242.30
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HYBHM1011100UG TNF-RII, Mouse, mAb HM102, 100 µg 100 µg
CA$909.00
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HYBHM101110MG TNF-RII, Mouse, mAb HM102, 10 mg 10 mg
CA$13,625.00
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HYBHM10111MG TNF-RII, Mouse, mAb HM102, 1 mg 1 mg
CA$2,725.00
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HYBHM1011500UG TNF-RII, Mouse, mAb HM102, 500 µg 500 µg
CA$1,912.00
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HYBHM10115MG TNF-RII, Mouse, mAb HM102, 5 mg 5 mg
CA$10,215.00
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