MCP-1, Mouse, Monoclonal Antibody ECE.2
- Supplier: Hycult Biotech
Product Description
- The monoclonal antibody ECE.2 recognizes mouse monocyte chemoattractant protein 1 (MCP-1)._x000D_ The murine JE gene encodes the monocyte-specific cytokine monocyte chemotactic protein 1 (MCP- 1). MCP-1 is a CC chemokine of 76 amino acids (~11 kDa) and is chemotactic for monocytes and_x000D_ basophils but not neutrophils and eosinophils. MCP-1 is expressed by smooth muscle cells (SMC),_x000D_ macrophages, endothelial cells, keratinocytes and fibroblasts in response to inflammatory stimuli such_x000D_as interleukin 1β and tumor necrosis factor α. MCP-1 has been implicated in a variety of inflammatory_x000D_ processes, including inflammatory bowel disease, rheumatoid arthritis, asthma, nephritis, and parasitic_x000D_ and viral infections. MCP-1 antigen is not detected in the endothelium or SMC of normal arteries._x000D_ MCP-1 has also been shown to exhibit biological activities other than chemotaxis. It can induce the_x000D_ proliferation and activation of killer cells known as CHAK (CC-Chemokine-activated killer) MCP-1 signals via the CCR2 receptor, and is critical for aneurysm formation because of its stability to_x000D_ recruit leukocytes. These leukocytes produce extracellular matrix-degrading MMPs, thereby inductin_x000D_ aortic remodelling and dilatation. Interleukin-6 is also involved in this amplification loop acceleratin vascular inflammation. MCP-/- mice display significantly delayed wound re-epithelialization, and also_x000D_delayed wound angiogenesis.
- Applications: Paraffin Sections , Western Blot
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHM101920UG | MCP-1, Mouse, mAb ECE.2, 20 µg | 20 µg |
CA$235.00
|
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| HYBHM1019100UG | MCP-1, Mouse, mAb ECE.2, 100 µg | 100 µg |
CA$573.00
|
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