Nectin-3, Mouse, Monoclonal Antibody 103-A1
- Supplier: Hycult Biotech
Product Description
- The monoclonal antibody 103-A1 recognizes mouse nectin-3. Nectin-3 is a 83 kDa type I_x000D_
- transmembrane glycoprotein. Nectin, originally isolated as poliovirus receptor-related protein (PRR), is_x000D_
- a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectins are calciumindependent_x000D_
- immunoglobulin-like cell-cell adhesion molecules consisting of four members, nectin 1-4._x000D_
- Nectins homophilically and heterophilically trans-interact to form a variety of cell-cell junctions,_x000D_
- including cadherin-based adherens junctions in epithelial cells and fibroblasts in culture, synaptic_x000D_
- junctions in neurons, and Sertoli cell-spermatid junctions in testis, in cooperation with, or_x000D_
- independently of, cadherins. Both nectin-2 and nectin-3 are ubiquitously expressed, whereas nectin-1_x000D_
- is abundantly expressed in brain. Nectin-2 and -3 are expressed in cells where cadherin is not_x000D_
- expressed, such as blood cells and spermatids. All members of the nectin family have two or three_x000D_
- splice variants. For nectin-3, three isoforms exist: nectin-3α, -3β and -3g of which nectin-3α is the_x000D_
- largest. Nectin-3, also known as PRR3, is a transmembrane protein that is predominantly expressed_x000D_
- in testis and placental tissues as well in many cell lines. Nectin interacts in vivo with both long and_x000D_
- short isoforms of afadin, an actin binding protein, at cadherin-based cell-cell adherence junctions in_x000D_
- various tissues and cell lines. Furthermore, the ectodomains of nectin-3 and CD155 (Poliovirus_x000D_
- Receptor) have shown strong affinity to each other._x000D_
- Injection of antibody 103-A1 into lumen of seminiferous tubules leads to disruption of the actin_x000D_
- filaments in Sertoli cells at the Sertoli-maturing spermatid ectoplasmic specialization and exfoliation of_x000D_
- maturing spermatids form the seminiferous epithelium.
- Applications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Immunofluorescence , Immunoprecipitation
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHM105320UG | Nectin-3, Mouse, mAb 103-A1, 20 µg | 20 µg |
CA$235.00
|
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| HYBHM1053100UG | Nectin-3, Mouse, mAb 103-A1, 100 µg | 100 µg |
CA$794.00
|
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