Hycult Biotech

Collagen II, Mouse, Monoclonal Antibody CIIC1

Product Description

  • The monoclonal antibody CIICI reacts with the C1 epitope (triple helical position 358-364) of collagen type II. Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA). The monocolonal antibody CIIC1 has been shown to induce CAIA in naïve mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody M2139, binding to the J1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity. The monoclonal antibody CIIC1 is cross reactive with rat, bovine, chicken and human CII.
  • Applications: Frozen sections, Functional Studies , Immunoassays , Paraffin Sections

Resources

Product Options

Product Number Description Package Size List Price (CAD)
HYBHM106220UG Collagen II, Mouse, mAb CIIC1, 20 µg 20 µg
CA$242.30
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HYBHM1062100UG Collagen II, Mouse, mAb CIIC1, 100 µg 100 µg
CA$666.00
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HYBHM106210MG Collagen II, Mouse, mAb CIIC1, 10 mg 10 mg
CA$13,625.00
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HYBHM10621MG Collagen II, Mouse, mAb CIIC1, 1 mg 1 mg
CA$2,725.00
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HYBHM1062500UG Collagen II, Mouse, mAb CIIC1, 500 µg 500 µg
CA$1,912.00
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HYBHM10625MG Collagen II, Mouse, mAb CIIC1, 5 mg 5 mg
CA$10,215.00
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