Hycult Biotech

TNF-alpha, Human, Monoclonal Antibody 52B83

Product Description

  • The monoclonal antibody 52B83 reacts with tumor necrosis factor alpha (TNF-alpha). TNF-alpha is a homotrimeric 17 kDa protein, that interacts with either one of the two types of TNF-receptors, termed I and II, leading to receptor cross-linking and signal transduction. The receptors differ strongly in their intra-cellular signaling pathways._x000D_
  • TNF-alpha was originally described as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Furthermore,- TNF-alpha is found to be a central mediator in many inflammatory and immunological processes. It can be induced by various products of micro-organisms and by various cytokines leading to expression of a wide variety of- cytokines. The pro-inflammatory properties of- TNF-alpha play a central role in several auto-immune diseases such as rheumatoid arthritis and inhibition by neutralizing molecules have been shown to be beneficial in patients.
  • Applications: Frozen sections, Flow Cytometry , Paraffin sections , Western Blot

Resources

Product Options

Product Number Description Package Size List Price (CAD)
HYBHM201020UG TNF-alpha, Human, mAb 52B83, 20 µg 20 µg
CA$242.30
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HYBHM2010100UG TNF-alpha, Human, mAb 52B83, 100 µg 100 µg
CA$592.00
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