TNF-alpha, Human, Monoclonal Antibody 52B83
- Supplier: Hycult Biotech
Product Description
- The monoclonal antibody 52B83 reacts with tumor necrosis factor alpha (TNF-alpha). TNF-alpha is a homotrimeric 17 kDa protein, that interacts with either one of the two types of TNF-receptors, termed I and II, leading to receptor cross-linking and signal transduction. The receptors differ strongly in their intra-cellular signaling pathways._x000D_
- TNF-alpha was originally described as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Furthermore,- TNF-alpha is found to be a central mediator in many inflammatory and immunological processes. It can be induced by various products of micro-organisms and by various cytokines leading to expression of a wide variety of- cytokines. The pro-inflammatory properties of- TNF-alpha play a central role in several auto-immune diseases such as rheumatoid arthritis and inhibition by neutralizing molecules have been shown to be beneficial in patients.
- Applications: Frozen sections, Flow Cytometry , Paraffin sections , Western Blot
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHM201020UG | TNF-alpha, Human, mAb 52B83, 20 µg | 20 µg |
CA$235.00
|
Add to Cart | |
| HYBHM2010100UG | TNF-alpha, Human, mAb 52B83, 100 µg | 100 µg |
CA$573.00
|
Add to Cart |
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