Hycult Biotech

Mannose receptor, Human, Monoclonal Antibody 15-2

Product Description

  • The monoclonal antibody 15-2 recognizes the mannose receptor (MR), also known as CD206, a member of the vertebrate C-type lectin family. The mannose receptor, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 175 kDa single-pass type I transmembrane receptor consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail._x000D_
  • The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR binds high-mannose structures on- a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator._x000D_
  • MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells. The expression of MR on monocytes increases during culture and can be enhanced by cytokines as IFN-gamma. Labeling of MR expressing monocytes/macrophages increases with prolonged incubation time probably due to internalization of the MR-antibody-complex. The monoclonal antibody 15-2 prevents binding of glycoproteins including t-PA to MR._x000D_
  • Detection of the MR with anti-MR monoclonal antibody 15-2 can substitute staining for mannose containing probes as labeled mannosylated BSA, a technique which is more cumbersome and less specific.
  • Applications: Frozen sections, Flow Cytometry , Functional Studies , Western Blot

Resources

Product Options

Product Number Description Package Size List Price (CAD)
HYBHM205620UG Mannose receptor, Human, mAb 15-2, 20 µg 20 µg
CA$242.30
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HYBHM2056100UG Mannose receptor, Human, mAb 15-2, 100 µg 100 µg
CA$909.00
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HYBHM205610MG Mannose receptor, Human, mAb 15-2, 10 mg 10 mg
CA$13,625.00
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HYBHM20561MG Mannose receptor, Human, mAb 15-2, 1 mg 1 mg
CA$2,725.00
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HYBHM2056500UG Mannose receptor, Human, mAb 15-2, 500 µg 500 µg
CA$1,912.00
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HYBHM20565MG Mannose receptor, Human, mAb 15-2, 5 mg 5 mg
CA$10,215.00
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