Mannose receptor, Human, Monoclonal Antibody 15-2
- Supplier: Hycult Biotech
Product Description
- The monoclonal antibody 15-2 recognizes the mannose receptor (MR), also known as CD206, a member of the vertebrate C-type lectin family. The mannose receptor, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 175 kDa single-pass type I transmembrane receptor consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail._x000D_
- The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR binds high-mannose structures on- a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator._x000D_
- MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells. The expression of MR on monocytes increases during culture and can be enhanced by cytokines as IFN-gamma. Labeling of MR expressing monocytes/macrophages increases with prolonged incubation time probably due to internalization of the MR-antibody-complex. The monoclonal antibody 15-2 prevents binding of glycoproteins including t-PA to MR._x000D_
- Detection of the MR with anti-MR monoclonal antibody 15-2 can substitute staining for mannose containing probes as labeled mannosylated BSA, a technique which is more cumbersome and less specific.
- Applications: Frozen sections, Flow Cytometry , Functional Studies , Western Blot
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHM205620UG | Mannose receptor, Human, mAb 15-2, 20 µg | 20 µg |
CA$242.30
|
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| HYBHM2056100UG | Mannose receptor, Human, mAb 15-2, 100 µg | 100 µg |
CA$909.00
|
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| HYBHM205610MG | Mannose receptor, Human, mAb 15-2, 10 mg | 10 mg |
CA$13,625.00
|
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| HYBHM20561MG | Mannose receptor, Human, mAb 15-2, 1 mg | 1 mg |
CA$2,725.00
|
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| HYBHM2056500UG | Mannose receptor, Human, mAb 15-2, 500 µg | 500 µg |
CA$1,912.00
|
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| HYBHM20565MG | Mannose receptor, Human, mAb 15-2, 5 mg | 5 mg |
CA$10,215.00
|
Add to Cart |
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