Hycult Biotech

CD46, Human, Monoclonal Antibody M177

Product Description

  • The monoclonal antibody M177 recognizes CD46, also designated membrane cofactor protein (MCP). CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity.- It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to inhibit complement activation on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus._x000D_
  • Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). The monoclonal antibody M177 reacts with the SCR2 domain
  • Applications: Flow Cytometry , Functional Studies , Immunoassays , Immunoprecipitation , Western Blot

Resources

Product Options

Product Number Description Package Size List Price (CAD)
HYBHM210320UG CD46, Human, mAb M177, 20 µg 20 µg
CA$242.30
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HYBHM2103100UG CD46, Human, mAb M177, 100 µg 100 µg
CA$734.00
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HYBHM210310MG CD46, Human, mAb M177, 10 mg 10 mg
CA$13,625.00
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HYBHM21031MG CD46, Human, mAb M177, 1 mg 1 mg
CA$2,725.00
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HYBHM2103500UG CD46, Human, mAb M177, 500 µg 500 µg
CA$1,912.00
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HYBHM21035MG CD46, Human, mAb M177, 5 mg 5 mg
CA$10,215.00
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