Hycult Biotech

Activated C1s, Human, Monoclonal Antibody M241

Product Description

  • Monoclonal antibody M241 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen of 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s.
  • Applications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Immunoprecipitation , Paraffin sections , Western Blot

Resources

Product Options

Product Number Description Package Size List Price (CAD)
HYBHM210920UG Activated C1s, Human, mAb M241, 20 µg 20 µg
CA$242.30
Add to Cart
HYBHM2109100UG Activated C1s, Human, mAb M241, 100 µg 100 µg
CA$821.00
Add to Cart

List Prices are displayed.

Please register or log-in to the site to view your organization’s prices, or please add the products to your cart and click the “Request a Quote” button to receive price and availability information (include quantities for each product and indicate either a one-time purchase or your annual usage.)