Activated C1s, Human, Monoclonal Antibody M241
- Supplier: Hycult Biotech
Product Description
- Monoclonal antibody M241 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen of 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s.
- Applications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Immunoprecipitation , Paraffin sections , Western Blot
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Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHM210920UG | Activated C1s, Human, mAb M241, 20 µg | 20 µg |
CA$235.00
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| HYBHM2109100UG | Activated C1s, Human, mAb M241, 100 µg | 100 µg |
CA$794.00
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