CD36, Human, Monoclonal Antibody FA6-152
- Supplier: Hycult Biotech
Product Description
- Monoclonal antibody FA6-152 recognizes human CD36 (88-kDa), a cell surface class B scavenger_x000D_ receptor, also known as thrombospondin receptor CD36 is a heavily N-glycosylated transmembrane_x000D_ protein of ~88 kDa with two short intracellular domains and a large extracellular domain. The protein is_x000D_ sensitive for neuroaminidase, resulting in a shift from 88 to 85 kDa. CD36 is expressed on platelets,_x000D_mature monocytes and macrophages, microvascular endothelial cells, mammary endothelial cells,_x000D_ during stages of erythroid cell development and on some macrophage derived dendritic cells. The_x000D_ antibody recognizes adult and fetal monocytes, platelets and reticulocytes, but doesn’t stain_x000D_ lymphocytes and granulocytes. Reactivity has also been found in small intestine, kidney, liver and_x000D_ thyroid. CD36 expression is primarily controlled by the transcription heterodimer PPARg-RXR_x000D_ (peroxisome proliferator-activated receptor-g-retinoid-X-receptor). CD36 is preferentially found within lipid rafts, which facilitates its association with receptors, signaling and adaptor molecules. It is a_x000D_ receptor and transporter of oxidized lipids and long chain fatty acids. CD36 has been implicated in_x000D_ many biological processes including angiogenesis, phagocytosis, inflammation, and lipid and glucose_x000D_ metabolism. Several in vivo models support the role of the thrombospondin / CD36 system in_x000D_ angiogenesis and tumor growth. An important role for CD36 has been found in Malaria as major_x000D_ receptor for P. falciparum-infected red blood cells. CD36 is associated with Src-family kinases and_x000D_with the integrins α3β1 and α6β1. Recently, CD36 has been identified as a protein that is required for_x000D_ toll like receptor (TLR2) recognition of di-acylated bacterial lipopeptides and lipoteichoic acid4._x000D_ Furthermore, CD36 has been shown to function as phagocytic receptor for apoptotic cells. Many_x000D_ different ligands have been reported to interact with CD36, suggesting that CD36 could recognize a_x000D_ structure-based domain rather than specific contact residues. Monoclonal antibody FA6-152 blocks_x000D_ the biological activity of CD36 by blocking collagen/thrombospondin binding. The antibody_x000D_ agglutinates fetal but not adult erythrocytes.
- Applications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Immunofluorescence , Immunoprecipitation
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHM212220UG | CD36, Human, mAb FA6-152, 20 µg | 20 µg |
CA$242.30
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| HYBHM2122100UG | CD36, Human, mAb FA6-152, 100 µg | 100 µg |
CA$592.00
|
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| HYBHM212210MG | CD36, Human, mAb FA6-152, 10 mg | 10 mg |
CA$13,625.00
|
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| HYBHM21221MG | CD36, Human, mAb FA6-152, 1 mg | 1 mg |
CA$2,725.00
|
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| HYBHM2122500UG | CD36, Human, mAb FA6-152, 500 µg | 500 µg |
CA$1,912.00
|
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| HYBHM21225MG | CD36, Human, mAb FA6-152, 5 mg | 5 mg |
CA$10,215.00
|
Add to Cart |
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