C3d, Human, Monoclonal Antibody 3
- Supplier: Hycult Biotech
Product Description
- The monocolonal antibody 3 (also known as YB2/39-11-1-7) reacts with a linear determinant in C3d. This 'D' antigen is found on C3, C3b, iC3b, C3dg and C3d. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/ml. An inherited deficiency of C3 predisposes the person to frequent bacterial infections. C3 fragments are deposited in tissues at sites of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by C3-convertases results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. C3dg can be cleaved into C3d and C3g, though this does not occur in plasma. The monoclonal antibody 3 recognizes C3, C3b, iC3b, C3dg and C3d. The monoclonal antibody does not recognize C3c. To distinguish C3 from C3b an anti-C3a antibody is necessary (HM2074).
- Applications: Immunoassays , Immunoprecipitation
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHM219820UG | C3d, Human, mAb 3, 20 µg | 20 µg |
CA$242.30
|
Add to Cart | |
| HYBHM2198100UG | C3d, Human, mAb 3, 100 µg | 100 µg |
CA$821.00
|
Add to Cart | |
| HYBHM2198500UG | C3d, Human, mAb 3, 500 µg | 500 µg |
CA$1,912.00
|
Add to Cart |
List Prices are displayed.
Please register or log-in to the site to view your organization’s prices, or please add the products to your cart and click the “Request a Quote” button to receive price and availability information (include quantities for each product and indicate either a one-time purchase or your annual usage.)