TNF-alpha, Human, Monoclonal Antibody 5N
- Supplier: Hycult Biotech
Product Description
- The monoclonal antibody 5N reacts with Tumor Necrosis Factor alpha (TNF-alpha). Tumor necrosis factor-alpha (TNF-alpha), a homotrimeric 17 KD protein, is a potent mediator of inflammatory and metabolic functions. TNF-alpha was originally detected as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Further TNF-alpha has been implied as central mediator in shock induced by gram negative micro-organisms. The cytokine TNF-alpha is found to be a central mediator in many inflammatory and immunological processes: it can be induced by various products of micro-organisms and by various cytokines but it also induces on its turn the production of many cytokines. Signal transduction occurs via two types of TNF-receptors, the TNF-receptors I and II. The receptors differ strongly in their intra-cellular signaling pathways. The TNF-alpha trimer interacts with either of the two types of TNF-R leading to receptor cross-linking. The monoclonal antibody 5N cross-reacts and cross-neutralizes all monkey species TNF-alpha, except pig-tail macaque. With affinity about two orders lower it recognizes bovine and canine TNF-alpha.
- Applications: Functional Studies , Immunoassays
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHM221820UG | TNF-alpha, Human, mAb 5N, 20 µg | 20 µg |
CA$242.30
|
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| HYBHM2218100UG | TNF-alpha, Human, mAb 5N, 100 µg | 100 µg |
CA$666.00
|
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| HYBHM2218500UG | TNF-alpha, Human, mAb 5N, 500 µg | 500 µg |
CA$1,912.00
|
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