Amyloid beta 40, Human, Monoclonal Antibody VU-17
- Supplier: Hycult Biotech
Product Description
- Antibody clone VU17, formerly known as αVU Aß 17, recognizes the N-terminus of human amyloid beta (i.e. in: Aβ1-38; Aβ1-39; Aβ1-40; Aβ1-42). Amyloid beta peptides are of key importance in the development of Alzheimer’s disease (AD) and are present in CSF. AD affects approximately 1% of the population over the age of 80. The disease is characterized by aggregation of Aβ into oligomers, fibrils and plaques deposition of insoluble and aggregated protein in the brain where its neurotoxic action leads to neuronal cell death. The deposits, also called amyloid plaques, are formed around the neuropil. The exact molecular mechanism is still unclear. Aβ is a proteolytic cleavage product, by APP-cleaving enzyme 1 (BACE1) and β-secretase complex, of membrane bound amyloid precursor protein (APP). Amyloid is the term used for proteins that are misfolded into a cross β-sheet structure. Aβ is produced by various cell types and is secreted in the interstitial fluid. There are multiple cleavage sites in Aβ domain leading to various fragments of 36-43 amino acids in length. The main peptide in the CSF terminate at residue 40. CSF contains many Aβ isoforms, of which Aβ40 is approximately 10 times more abundant than Aβ42. Aβ40 levels are unchanged in AD, but there is a change in Ab40:Aβ42 ratio in AD. This ratio has been thought of diagnostic importance. Assessment of Aβ in brain tissue is essential for diagnosis and is crucial for investigating the molecular mechanisms underlying AD. _x000D_
- Antibody VU17 is raised against the N-terminus of Aβ. The antibody detects all forms of Aβ deposits without the need for formic acid pre-treatment on paraffin coupes and can be applied in a double staining strategy, making it suitable for investigating co-localization.
- Applications: Immunoassays , Immunoprecipitation , Paraffin sections , Western Blot
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHM232520UG | Amyloid beta 40, Human, mAb VU-17, 20 µg | 20 µg |
CA$242.30
|
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| HYBHM2325100UG | Amyloid beta 40, Human, mAb VU-17, 100 µg | 100 µg |
CA$666.00
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