C5b-9, Rat, Monoclonal Antibody 2A1
- Supplier: Hycult Biotech
Product Description
- The monoclonal antibody 2A1 recognizes rat C5b-9. The antibody was shown to compete with antibodies to human C9 for its binding site on the C5b-9 complex, indicating that the reactive epitope is located on the C9 molecule. C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive.C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated._x000D_
- The monoclonal antibody 2A1 was raised against a rat C5b-9 neoantigen. Monoclonal antibody 2A1 can be used as a coating antibody to detect C5b-9 in plasma and urine samples.
- Applications: Frozen sections, Flow Cytometry , Immunoassays , Immunofluorescence , Paraffin sections , Western Blot
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHM303320UG | C5b-9, Rat, mAb 2A1, 20 µg | 20 µg |
CA$242.30
|
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| HYBHM3033100UG | C5b-9, Rat, mAb 2A1, 100 µg | 100 µg |
CA$734.00
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| HYBHM3033500UG | C5b-9, Rat, mAb 2A1, 500 µg | 500 µg |
CA$1,912.00
|
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