Lipid A, Monoclonal Antibody 26-5
- Supplier: Hycult Biotech
Product Description
- The monoclonal antibody 26-5 recognizes lipid A. The lipid A domain of lipopolysaccharide (LPS) is aunique, glucosamine-based phospholipid that makes up the outer monolayer of the outer membrane ofmost gram-negative bacteria.Lipid A is responsible for the endotoxic activities of LPS, and a heteropolysaccharide. Theheteropolysaccharide generally consists of an oligosaccharide termed the core region. This core regionis in some bacterial families composed of repeating oligosaccharide units, the so-called O chain. Thelipid A moiety of LPS is detected by the TLR4/MD2 receptor of the mammalian innate immune system.Picomolar levels of lipid A induce macrophages to synthesize potent mediators of inflammation, such asTNF-α and IL-1β. Furthermore, lipid A activates the production of costimulatory molecules required foradaptive immunity and stimulates tissue factor production in mononuclear and endothelial cells. Allthese events are desirable for clearing local infections.
- Applications: Immunoassays
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHM600920UG | Lipid A, mAb 26-5, 20 µg | 20 µg |
CA$242.30
|
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| HYBHM6009100UG | Lipid A, mAb 26-5, 100 µg | 100 µg |
CA$821.00
|
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