Spi-6, Mouse, Polyclonal Antibody
- Supplier: Hycult Biotech
Product Description
- The polyclonal antibody recognizes mouse Spi-6, also known as serpin B9, a cytoplasmic serine protease inhibitor of ~42 kD. Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune-privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer. The polyclonal antibody shows no crossreactivity with mouse proteins related to Spi-6.
- Applications: Flow Cytometry , Western Blot
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHP803520UG | Spi-6, Mouse, pAb, 20 µg | 20 µg |
CA$242.30
|
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| HYBHP8035100UG | Spi-6, Mouse, pAb, 100 µg | 100 µg |
CA$734.00
|
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