HAKAI, Human, Polyclonal Antibody
- Supplier: Hycult Biotech
Product Description
- The polyclonal antibody reacts with human Hakai, a c-Cbl-like protein. Hakai is an E-cadherin binding protein, which has been identified as an E3 ubiquitin-ligase. Hakai contains SH2, RING, zinc-finger and proline-rich domains. Hakai interacts with E-cadherin in a tyrosine phosphorylation-dependent manner, inducing ubiquitination of the E-cadherin complex. Expression of Hakai in epithelial cells disrupts cell-cell contacts and enhances endocytosis of E-cadherin and cell motility. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai is able to control epithelial-mesenchymal transitions under physiological and pathological conditions.
- Applications: Frozen sections, Immunofluorescence , Western Blot
Resources
Product Options
| Product Number | Description | Package Size | List Price (CAD) | ||
|---|---|---|---|---|---|
| HYBHP903820UG | HAKAI, Human, pAb, 20 µg | 20 µg |
CA$242.30
|
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| HYBHP9038100UG | HAKAI, Human, pAb, 100 µg | 100 µg |
CA$821.00
|
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