March 2018
Dear Researcher,
We are pleased to present the e-Lynx, a newsletter devoted to keeping our customers up-to-date on new technologies, our new products, suppliers, activities and promotions.
- New Products
- New Products from Our Sister Company
- New Literature
- New Video
- Technical Report
- Promotions
- MJSBioLynx Well Being
NEW PRODUCTS
Biosensing Instrument – SPRm 200 Surface Plasmon Resonance Microscopy System
Simultaneous optical imaging with SPR measurements.
The Surface Plasmon Resonance Microscopy (SPRM) system integrates optical microscopy and SPR to offer a powerful technique for measuring the binding activities of membrane proteins in vitro. It allows the simultaneous measurement of phenotypical changes of the sample via bright field and binding strength and kinetics via SPR.
- Integrated optical microscopy with SPR Bright-field and SPR microscopy in one instrument. Large field of view with high resolution optics to view single or multiple cells
- In vitro and label-free binding activities mapping Provides SPR sensorgrams and binding activity map of individual cells as well as the binding kinetic constants (ka, kd, KD)
- Nanometer scaled binding response of virus, bacteria and nanoparticles Nanomotion detection study of bacteria or virus metabolic activity or binding activities of nanoparticles for drug delivery designs
Click here for more information.
Click here to order or request a quote.
Hycult Biotech - Proteinase 3 and sCD59 ELISA Kits
Proteinase 3: only for ANCA-associated vasculitis?
The Proteinase 3 enzyme, also known as PRTN3 or PR3, is a serine protease that is mainly expressed by neutrophil granulocytes.
Studies in the eighties and nineties already suggest an interaction between PR3 and emphysema, but also with an enhanced platelet response. A recent study underlines that PR3 is one of the key regulators in Wegener granulomatosis (GPA), which is one of the variants of ANCA-associated vasculitis. Besides inducing other auto-immune diseases such as rheumatoid arthritis and glomerulonephritis, a 2017 study established that the interaction between PR3 and RAGE (a cell surface receptor expressed on malignant cells) mediates homing and metastasis of prostate cancer cells to the bone marrow.
Even though a majority of studies using PR3 are historically related to vasculitis, there is an unprecedented number of autoimmune diseases and interactions within tumor immunology where the role of PR3 still has to be determined.
Click here to order or request a quote.
sCD59: from inflammation to transplantation.
CD59, also known as the MAC-inhibitory protein, is a complement regulatory glycoprotein that inhibits membrane attack complex formation by preventing C9 from polymerizing. The soluble form of CD59 can be detected in a variety of body fluids and is associated with a range of different conditions. A paper from 1995 for example describes the role of CD59 in glomerulonephritis and in that same year there was a paper discussing the therapeutic potential of CD59 in inflammatory diseases.
Historically there have also been scientific articles specifying the role of this protein in relation to myocardial infarction, carcinoma, PNH and macular degeneration. The glycated form of CD59 also shows to be a useful marker for diabetes. Recent insights have further demonstrated that the soluble form of CD59 plays an important role in allograft rejection after transplantation. All these findings combined confirm that CD59 is a versatile regulatory protein that will remain a relevant target for scientific exploration of complement-mediated conditions.
Click here to order or request a quote.
Labnet - C0336 and C0336R High Performance Centrifuges
These high performance centrifuges are capable of high speed operation, expanding their use to applications in molecular biology and basic research.
Max Speed:90 - 18,000 rpm, step 1 RPM- Max RCF: 24,270 x g, step 1 x g
- Max Volume:500 mL
- Temperature Range (C0336R):-20C to +40C, step 1C
- Maintenance-free induction motor
- 100 user programs
- Continuous and short time operation modes
- Programming of multi-segment acceleration and deceleration characteristics
- Password protection
Click here for more information.
Click here to order or request a quote.
NEW PRODUCTS FROM OUR SISTER COMPANY
Knauer – Azura® SMB for Multi-column or Batch LC
- Modular system designed to separate biomolecules or small molecules
- Upgrade kits allow other configurations to be implemented easily such as batch configuration or the addition of a column thermostat
- The PurityChrom® MCC software provides an interactive visualization of the installed system, giving you the opportunity to keep track of all important parameters
The ability to add more modules to the system as needed (such as pumps, valves, or detectors) and control all different operating modes with the same software makes it easy to handle and avoids compatibility issues that might arise when using heterogeneous system environments and configurations. Training effort is also minimized with the AZURA solution.
Click here for the video.
Click here for more information.
Click here to contact our Instrumentation Team.
Knauer products are available to us through our sister company, Chromatographic Specialties Inc.
NEW LITERATURE
Micronic – 2018 Sample Preservation and Storage Solutions Catalogue
Micronic offers 2D coded and non-coded sampling and tracing solutions. Their products include tubes, scanners, cappers/decappers and sample management software.
Click here to request a PDF copy.
Click here to request a printed copy.
Matreya – February 2018 Newsletter for Glyco/Sphingolipid Research
In this issue: The Role of Sulfatides in Various Diseases, Sterculic Acid Inhibits Toxoplasma Gondii, and Potent Effects of Conjugated Linolenic Acids.
Click here to view the PDF.
NEW VIDEO
Mirus – Recorded Webinar: Best practices in transfection: Impacts on gene editing, virus production, and more
Transfection of cells in culture is a key technique in the molecular and cell biology toolbox. Toxicity and efficiency are the factors that have the biggest impact on the success of transfection experiments and can significantly affect important downstream applications. In this webinar, we discuss the key steps and protocol considerations for performing high-quality transfections on a consistent basis, taking into consideration variables such as cell type, culture conditions, reagent concentrations, and other critical parameters. Drawing attention to these factors will ultimately lead to better downstream results for gene expression and other emerging applications, such as CRISPR/Cas9 genome editing, virus production, and cell-line development for biotherapeutic protein production.
Click here to watch. (Link to Science AAAS website)
TECHNICAL REPORT
Vector Laboratories - A Simple Method for Dramatic Reduction of Tissue Autofluorescence
Autofluorescence originating from native tissue components and aldehyde fixation often impairs or prevents the use of immunofluorescence assays. Multiple tissue components such as red blood cells, elastin, and collagen can generate strong fluorescent signals making it difficult to discern between specific signal and background.
Currently available methods for reduction of tissue autofluorescence are not broadly effective and often reduce immunofluorescence signal by a similar amount resulting in little, if any, improvement in signal to noise.
Here we demonstrate an effective reduction of autofluorescence using a novel reagent that improves signal-to-noise and thus enhancing detection of specific signal. The procedure is simple, rapid, broad spectrum and applied post assay.
Click here to read more.
PROMOTIONS
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Micronic – 2018 Kick-off Bundle Deals
Offers end March 31st, 2018
These offers will help improve your workflow by automating the process of (de)capping sample storage tubes. You can also ensure complete traceability of your tissue samples with the Tissue Storage Starter Pack.
Buy a Screw Cap Recapper SR008 and Screw Caps with a 20% Bundle Discount
The Recapper SR008 handheld device offers users the ability to cap, decap or recap a row of 8 tubes in less than 5 seconds! This system minimizes sample evaporation, significantly improves productivity, and ensures each screw cap is tightened securely and uniformly.
Click here to order.
Buy a Push Cap Capper CM480 and Push Caps with a 20% Bundle Discount
The CM480 Capper offers a cost effective way of applying uniform pressure to push caps in an entire 96 tubes rack in only a single action.
Click here to order.
Buy a Tissue Storage Starter Pack with 1.00mL or 3.50mL Tubes with a 20% Bundle Discount*
Micronic Starter Packs contain everything needed to start using 2D coded sample storage tubes, enabling laboratory workers to maintain a secure sample logistics system and eliminate the costly possibility of false sample identities.
Click here to order.
Offers Valid until March 31st, 2018.
Cannot be combined with other offers or discounts.
*Compared to price of purchasing products separately.
USA Scientific - FREE Pizza Party Promotion
Offer ends March 31st, 2018
For the cold Canadian winter months of January to March 2018, enjoy hot, delicious pizza on us!
Accumulate $500 in Purchases of USA Scientific Products from MJSBioLynx and Receive a $50 Pizza Gift Certificate*.
USA Scientific offers cell culture labware, pipets and tips, plates, tubes and much more.
Click here to order or to request a quote.
Please reference Promotion Code US2018PZA.
Offer valid until March 31st, 2018.
Limit: Two pizza parties per lab; Cannot be combined with other offers.
* Please note that if you purchase $500 in USA Scientific products during our promotion period but are unable to accept our pizza gift we would be pleased to offer you a $50 voucher towards your next order of $100 or more of USA Scientific products. Coupons are valid until April 30th, 2018.
MJSBioLynx WELL BEING
Meditation Can Make You A Better Athlete: Here's How & Why
"As an athlet
e, being at the top of your game doesn’t only involve hours of practice and dedication to the weight room. There are mental capacities that need honing in order to heighten performance. While being a top-notch sports player is a physical feat, the mental game is just as important. When athletes become more aware of their bodies, they also build inner resilience to handle stress, which unlocks elevated performance levels. In essence, mindfulness training can grow the inner capacities of distress tolerance, present-moment awareness, and acute focus to fuel what athletes seek most—results."
Click here to read more. (Link to mbgmindfulness Website)
Click here to visit the MJSBioLynx Well Being website