Dear Researcher,
We are pleased to present the e-Lynx, a newsletter devoted to keeping our customers up-to-date on new technologies,
our new products, suppliers, activities and promotions.
- MJSBioLynx Well Being
- NEW PRODUCTS
- FEATURED PRODUCTS
- Mirus Bio
- MicronPlus – Pattern Adhesive Sealing Films
- NEST Biotechnology – ELISA, Deep Well, and PCR 96-Well Plates
- ANNOUNCEMENTS
- COME AND MEET US!
- PROMOTIONS
- NEW LITERATURE
- TECHNICAL REPORTS
MJSBioLynx Well Being
Why Humans are Surprisingly Bad at Being Happy
"Sometimes, it's really hard to be happy. And there's a reason for that. The human brain isn't hard-wired for happiness. Why? ... "
NEW PRODUCTS
EpiCypher – CUTANA™ CUT&RUN Services for Scaled Epigenomic Analyses
EpiCypher is pioneering the development of CUT&RUN chromatin mapping assays, which provide massive improvements in throughput, data quality, and sensitivity compared to ChIP-based methods. To meet the needs of their research partners, they have developed automated CUTANA™ CUT&RUN Services. Their services offer exclusive access to EpiCypher’s genomics experts, guaranteeing strong support from experimental design to data analysis. This turnkey solution delivers rapid, high-resolution chromatin mapping at scale – unlocking the epigenome to advance biological discovery.
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EpiCypher – DYKDDDDK Tag CUTANA™ CUT&RUN Antibody
- Type: Monoclonal
- Host: Rabbit
- Applications: CUT&RUN, ELISA, WB, IP, ICC
- Reactivity: FLAG® Epitope (DYKDDDDK)
- Format: Antigen affinity-purified
DYKDDDDK antibody is useful for studies utilizing FLAG®*-tagged target proteins. This antibody meets EpiCypher's “CUTANA Compatible” criteria for performance in Cleavage Under Targets and Release Using Nuclease (CUT&RUN) and/or Cleavage Under Targets and Tagmentation (CUT&Tag) approaches to genomic mapping.
*FLAG® is a registered trademark of Merck KGaA, Darmstadt, Germany.
EpiCypher – SNAP-CUTANA™ DYKDDDDK Tag Panel
The SNAP-CUTANA™ DYKDDDDK Tag Panel of spike-in controls for CUT&RUN offers an in-assay control to validate anti-FLAG®* antibodies and confirm the success of CUT&RUN reactions involving FLAG epitope-tagged chromatin proteins. This essential positive control guides troubleshooting to differentiate problems with FLAG epitope-tagging (including transgene expression, chromatin binding of the tagged protein, solvent accessibility of the tag, etc.) from technical failures in the CUT&RUN workflow.
EpiCypher – SNAP-CUTANA™ HA Tag Panel
The SNAP-CUTANA™ HA Tag Panel of spike-in controls for CUT&RUN offers an in-assay control to validate anti-HA antibodies and confirm the success of CUT&RUN reactions involving HA epitope-tagged chromatin proteins. This essential positive control guides troubleshooting to differentiate problems with HA epitope-tagging (including transgene expression, chromatin binding of the tagged protein, solvent accessibility of the tag, etc.) from technical failures in the CUT&RUN workflow.
Anatrace – CHEAPS (CH240): A Revolutionary Zwitterionic Cholesterol Derivative
Exciting News in Lipid Research!
Leveraging cutting-edge science, CHEAPS brings innovation to the field of Membrane Protein (MP) studies with its unique features:
- Novel Zwitterionic Sulfobetaine-based CHOL Alternative
- Readily solubilized in detergents
- Non-Hygroscopic and high Hydrophilic-Lipophilic Balance (HLB, 28.23)
- Hassle-free protein monitoring via UV-Vis
Features:
- 4-((cholesteryloxy)-4-oxobut-2-enamido)ethyl) dimethylam-monio) propane-1-sulfonate
- Formula Weight: 676.99
- Identity: IR spectrum confirms to specification
- Solubility: 1.2% in a 6% water solution of CHAPS
- Molecular Formula: C38H64N2O6S
References
Trinh, T. K. H., Qiu, W., Thornton, M., Carpenter, E. E., & Guo, Y. (2021). Biochimica et Biophysica Acta (BBA)-General Subjects, 1865(7), 129908.
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FEATURED PRODUCTS
Mirus Bio Receives ISO 13485:2016 Certification
Completion of this comprehensive certification process underscores the quality of the processes used to support the company’s GMP product portfolio.
Transfection is a Complex Process
Transfecting cells is a critical step in producing viral vectors for cell and gene therapies, manufacturing recombinant proteins and monoclonal antibodies for immunotherapies, editing genes through CRISPR, and applying a range of other applications such as silencing mRNA translation. Successful transfection requires navigating through several cellular barriers in a sequence of precisely orchestrated steps including:
DNA complexation- Cellular binding and uptake
- Endosomal release and cytoplasmic diffusion
- Nuclear transport
It’s complex. That’s why single component transfection reagents, whether they are polymers or lipids, are not sufficient to maximize efficiency of the process and retain cell viability.
Mirus Bio transfection technology include both proprietary polymer and lipid elements. This combination enables both high transfection efficiency and low cellular toxicity.
With Mirus’s transfection platforms, the polymer, lipid, and your nucleic acid come together to form a lipid polymer nanoparticle complex, which is effective at delivering cargo to nearly any cell type.
Mirus offers a range of effective transfection solutions and tools for a comprehensive set of cell lines. These solutions are intentionally designed to be gentle on cells and maximize cell delivery while using a simplified, straightforward protocol.
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MicronPlus – Pattern Adhesive Sealing Films
MicronPlus pattern adhesive sealing films for microplates are specifically designed to eliminate clogging and contamination of needles and offer the best optical clarity for inspection and diagnostic applications. These superior-performing seal films are suitable for many different applications.
- No adhesive interference with the contents of the wells
- No clogging or contamination of needles
- Fully tested and custom designed for all applications
- Samples Available – please contact tech@biolynx.ca
Pattern Adhesive Products (patented) available:
Silicone Patch • Silicone Mat • 384-Well Square • 384-Well Pre-Slit • 96-Well Square
96-Well Round • Seal Film Roll • Individual Tube Capping • Microplate Strip
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NEST Biotechnology – ELISA, Deep Well, and PCR 96-Well Plates
ELISA Plates
Features:
- Plates present good adsorption performance and low baseline value.
- Uniform thickness and size.
- High batch-to-batch stability and low coefficient of variation (CV) value.
- Both detachable and non-detachable flat-bottom plates are offered for customers to choose from based on their applications.
- The letters and numbers on the frame of the plates are convenient for detection and identification in experiments.
- High transparency of clear plate bottom.
- White plates are best suited for luminescence measurements as they reflect the signal instead of absorbing it and hence enhance the luminescence signals.
Deep Well Plates
Features:
- High quality imported PP material employed for high stability and no chemical reactions with test reagents.
- Compatible with DMSO and inert to water.
- Can be stored under subzero temperature from -40 to -80°C
- Maximum sustainable centrifuge force 4000g.
- Autoclavable at 20Psi, 121°C for 20 minutes, great heating uniformity.
- Minimum residual liquid, low heavy metal content.
- Certified DNase/RNase and Pyrogen Free.
- Conformed to international SBS Standards.
- Good flat and can be transported for long distance if sealed by heat sealable film.
- Produced and packed in Class 100,000 clean workshop.
- Alphabetical sorting and corner cut marking for convenient tracking of samples.
- Each package has a separate article number/batch number identification, facilitating the quality tracking.
PCR 96-Well Plates
Features:
- Made of high-quality polypropylene to ensure minimal loss of reaction solution.
- Flat surface, thick and solid, not easy to deform.
- The black ink-printing marks on the surface are easy to read and identify.
- Elevated edge of the hole can better prevent cross contamination.
- Compatible with NEST pressure sensitive film, self-adhesive film and hot sealing film.
- Autoclavable.
- The tube wall of transparent 96-well PCR Plate is thin, allowing for good light transmission.
- White PCR 96-well plate is better for qPCR experiments.
- The maximum capacity of the 0.1mL tube is 150 µL, and that of a 0.2 mL tube is 250 µL.
- Certified DNase/RNase and Pyrogen Free.
Further details on ELISA, Deep Well, and PCR 96-Well Plates:
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ANNOUNCEMENTS
We are pleased to announce that Quanta BioDesign is now part of Vector Laboratories
Quanta BioDesign is the inventor of discrete polyethylene glycol (dPEG®) technology for advanced bioconjugate and payload delivery design for life science and biopharma applications. Quanta BioDesign was the first manufacturer to offer commercially scalable single molecular weight PEG technology. Together, Vector and Quanta BioDesign combine linker and dye synthesis expertise with conjugation capabilities,
offering you a broad selection of products from a single vendor.
COME AND MEET US!
MJS BioLynx – March 2024 Shows
Come and say hello and find out how our products can help you with some of your research challenges.
| Date | Location | Time |
| March 6, 2024 | SDRI - UWO Conference Room SDRI-217, 2nd Floor |
10:00am - 11:30am |
| March 7, 2024 | St. Joseph's Hospital Juravinski Innovation Tower Lobby Miller side, 2nd Floor |
10:00am - 11:30am |
| March 7, 2024 | McMaster University - Health Science Centre Blue Room, Bldg. 37 |
1:30pm - 3:30pm |
| March 8, 2024 | Biochemistry & Biomedical Sciences Research Symposium (BBSRS) – McMaster University David Braley Health Science Centre |
10:30am - 2:45pm |
| March 13, 2024 | CHU de Québec - Université Laval Research Ctr. Hall, Bloc "T" (TR-02) |
10:00am - 11:30am |
| March 20, 2024 | 29th Annual Southern Alberta Scientific Equipment (SASE) Tradeshow Health Research Innovation Centre (HRIC) Atrium University of Calgary (Foothills Campus) |
9:00am - 2:00pm |
| March 26, 2024 | MaRS Centre - South Tower Conference Room CR3 |
9:30am - 11:30am |
| March 28, 2024 | Keenan Research Centre (LKSKI) Exhibition Hall, 2nd Floor |
10:30am - 12:30pm |
PROMOTIONS
MJS BioLynx and USA Scientific – Pizza Promotion
CHROMSPEC Flex Dollars – Are Your Budgets Coming to an End?
CHROMSPEC Flex Dollars can help you make the most of your money!
It’s difficult to know what supplies your work will require as you embark on new projects.
CHROMSPEC Flex Dollars are similar to pre-paid gift certificates that can be redeemed
for payment of future orders. Flex Dollars are available in $500.00 increments and
redeemable within 2 years of purchase.
MJS BioLynx – Instrumentation Sale!
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NEW LITERATURE
Coming Soon – New MJSBioLynx Cell Biology Brochure
We are in the process of completing our new Cell Biology Brochure, featuring Cell Culture Medium,
Tools for Exosome Research, Transfection, Advances in 3D Cell Culture, Cell Culture Labware, and more…
To receive your hardcopy or a PDF as soon as it is available, please request below:
TECHNICAL REPORTS
Vestibular Neuron Breakthrough Enabled by PeptiGel® and PODS®
Top CUT&RUN and CUT&Tag Chromatin Mapping Papers of 2023
Happy St. Patrick's Day!
The MJS BioLynx Team
