Surface Plasmon Resonance


Biosensing Instrument Incorporated is devoted to providing high-performance Surface Plasmon Resonance (SPR) instruments for creative research and efficient analysis. Using innovative designs, their instruments offer high sensitivity for detecting analytes of various sizes, a wide time response range for slow and fast kinetics, and maximum versatility and flexibility.

Applications Include:

  • Gene assays (e.g., single nucleotide polymorphism) and DNA/DNA interactions
  • Immunosensing (ligand-receptor, antibody-antigen, etc.)
  • DNA/protein, protein/protein and protein/drug interactions
  • Protein unfolding and conformational changes
  • Drug discovery and development

 

SPRm 200 Surface Plasmon Resonance Microscopy System

Simultaneous optical imaging with SPR measurements.

The Surface Plasmon Resonance Microscopy (SPRM) system integrates optical microscopy and SPR to offer a powerful technique for measuring the binding activities of membrane proteins in vitro.  It allows the simultaneous measurement of phenotypical changes of the sample via bright field and binding strength and kinetics via SPR.
 
  • Integrated optical microscopy with SPR Bright-field and SPR microscopy in one instrument. Large field of view with high resolution optics to view single or multiple cells
  • In vitro and label-free binding activities mapping Provides SPR sensorgrams and binding activity map of individual cells as well as the binding kinetic constants (ka, kd, KD)
  • Nanometer scaled binding response of virus, bacteria and nanoparticles Nanomotion detection study of bacteria or virus metabolic activity or binding activities of nanoparticles for drug delivery designs

 

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Biosensing Instrument – BI4500 Surface Plasmon Resonance Instrument

This system provides multiple channel flow modes and delivers high quality binding response for low immobilization and
small molecules (<100 Da) detection.
 
  • High throughput with 5 channels and fully automated sampling
  • High sensitivity to measure small molecules
  • Precise sample delivery with BI-DirectFlow™ technology
  • Innovative multi-module design for optimal flexibility
  • Cost-effective label-free analysis
     

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Biosensing Instrument – BI-2500 Surface Plasmon Resonance System

The ideal system for developing biosensors in your research. Its flexible design allows an upgrade path for electrochemical SPR or chemical vapor (gas) SPR combination studies.
 
  • Three-channel SPR detection module - Provides greater flexibility and faster assay development, doubling the throughput over two-channel SPR systems
  • Innovative multi-module design - Provides users with maximum flexibility to choose amongst various analysis modules for electrochemistry and chemical vapor applications
  • Wide dynamic range and high sensitivity - High sensitivity (<10-4 degrees) for both large and small molecules (<100 Daltons) enables users to measure binding constants down to a few pM-1
  • Broad response time - For slow (hours) and fast (< ms) kinetic processes
  • Cost effective - System has been designed with affordability in mind, brings SPR technology to your lab on your budget and with your own assay development schedule
     

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