New Products

Jena Bioscience - XtalTool All-in-One Tool for Sensitive Crystals

The patent-pending XtalTool was developed as a platform for protein X-ray crystallography to be used in all steps from crystallization, ligand soaking and data collection without any direct crystal handling. It is especially interesting for fragile crystals, for which any manipulation might disturb crystal packing and impair diffraction quality.

XtalTools replace regular cover slides used in 24-well hanging drop plates without compromising on optical parameters since crystal growth can be monitored using a regular microscope. The design of the XtalTool permits accurate addition and removal of ligand, fragment and / or cryoprotectant solutions without disturbance of the crystals.  Once crystals are prepared to the individual user's needs, the XtalTool can be directly used to collect crystallographic diffraction data at room or cryogenic temperature.  Its geometric design allows high compatibility with most synchrotron and in-house beamlines as it shares the standard 18 mm SPINE length of a regular sample holder.  The employed crystal supporting material is X-ray translucent and does not interfere with diffraction data collection.


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Micronic - 2.00mL and 3.00mL Tubes with External Thread Hybrid

The new tubes in 48-format guarantee sample traceability, optimize working volume and increase overall sample storage efficiency.

Sample traceability

The transparent part of the tube walls enable easy visual checking of the sample, while the 4 coding concepts guarantee sample traceability. Samples can be identified with the 2D Data-Matrix, 1D barcode, numeric human readable or by the written codes on the white surface of the tube. The unique combination of coding concepts, and the dimensions of the tubes, make the Hybrid tubes extremely versatile. The tubes are compatible with ANSI / SLAS format racks, standard cryo boxes, automated stores and liquid handlers.

Working volume

Externally threaded tubes also allow for a higher volume of material to be stored inside, which means that sample tubes can hold more while occupying the same amount of storage space. Compared to traditional cryo vials of similar dimensions, the 2.00ml and 3.00ml tubes provide 30% - 55% more working volume. The optimized working volume of the tubes increase the storage capacity of manual freezers and automated stores.

 

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USA Scientific – Layer4® Comfort gloves

Looking for a glove with dexterity, strength, and comfort? New Layer4® Comfort gloves meet the demanding needs of daily lab work. Manufactured with an advanced process that uses a minimal amount of surfactants, Layer4 Comfort gloves have an improved grip under wet conditions.

  • 100% latex-free with no natural rubber proteins
  • Low dermatitis potential means sensitive users can avoid the redness and itching of contact dermatitis associated with other formulations of nitrile gloves*
  • Quality assurance levels meet or exceed federal and ASTM tear and puncture-resistance standards
  • Non-sterile; passes viral penetration test (ASTM F1671) and is approved for medical use (FDA 510k)
     

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*This product has demonstrated reduced potential for sensitizing users to chemical additives. Warning: do not use this product if you have a known allergy to chemical additives.

Heathrow Scientific – MagFuge® Magnetic Stirrer and Centrifuge in One Unit

  • This design innovation enables a substantial cost and bench top space savings for laboratories by having two pieces of equipment in one
  • Easy to use with a digital display, one button programming and tool free rotor exchange
  • Stay focused in the lab with ultra-quiet operation
  • Reduce down-time with a reliable unit you can trust with 3-year warranty
  • Community Design No. 003515337-0001-0002 Euro. Pat. App. 3 246 088
  • US Design Patent No. D814,045
     

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Vector Laboratories – VECTASHIELD® Vibrance™ Antifade Mounting Medium

VECTASHIELD® Vibrance™ Antifade Mounting Medium prevents rapid photobleaching of fluorescent proteins and fluorescent dyes on cell and tissue section preparations.  It is supplied as an aqueous, ready-to-use formulation which will cure (set) over several hours at room temperature to immobilize the coverslip. No further sealing of the coverslip is required.

VECTASHIELD Vibrance Antifade Mounting Medium is compatible with the majority of commercially available fluorescent dyes.  The antifade properties of the medium are effective across the spectrum, including far red channels.

 

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Micronic – 0.40mL Tube with External Thread

The new 0.40mL tube is designed to perfectly fit into the TTP LabTech comPOUND sample store (D2 modus). The store can hold two 0.40ml tubes in each hole of its carousels, doubling the capacity. This special tube design provides the maximum sample storage capacity compared to all other available tube designs, the Micronic tube features the highest working volume of 0.40ml.

  • Triple start thread for optimal sealing quality
  • Improved sample integrity due to external thread (cross-contamination is minimized)
  • Thick tube walls and sturdy design for storage in ultra-low temperatures
  • Code surface has a raised edge to protect the 2D code
  • Black code surface cannot be separated from the transparent tube

 

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Heathrow Scientific – Magnetic Induction Stirrer

The Magnetic Induction Stirrer is motor-less, using advanced coil technology that produces the strongest magnetic coupling and has no moving parts making this unit 100% wear-free and maintenance free.

Several advantages come with a motor-less magnetic stirrer versus a traditional magnetic stirrer.

  • No heat is generated after hours of continuous use making this unit ideal for temperature sensitive samples and environments
  • Quiet operation and low vibration helps users stay focused in the lab
  • The magnetic field driving the stir bar maintains continuous constant speeds for reproducible results

 

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Micronic - Screw Cap Recapper CS700

Developed to improve efficiency, the recapper is ideal to standardize and automate a sample storage workflow. The device is optimal for high throughput workflows and to relieve researchers from repetitive manual labor.

  • Cycle time: (de)caps a whole rack of 96-, 48-, or 24-well format tubes in 30 seconds
  • Compatible with other brands of tubes
  • Operates as a stand-alone unit or in a fully automated environment (API's available)
  • Precise torque value for optimal sealing quality
  • Sensor cap detection that enhances process safety for automation
  • 3-year warranty

 

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Micronic – Screw Cap Ultra for Tubes with Internal Thread

The O-ring of the cap falls within the tube, creating a "hard" stop. This design enhances automated and manual handling (closure does not depend on the closing force of the cap but on fixed pressure) while also optimizing sealing performance.

  • Compatible with the Micronic Screw Cap Recappers and other automated systems
  • Available in 4 different premium ''pearl'' colours: blue, yellow, light green and red
  • Ideal for sample storage at ultra-low temperatures or for sample transportation
  • High-quality silicon O-ring
  • Resists chemical solvents
  • Certified class 7 clean room production
  • RNase/DNase and Pyrogen free

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Platypus Technologies – Silver Coated Substrates

  • Silver coated silicon wafers, microscope slides and coverslips
  • Fabrication in cleanroom environment
  • Electron beam deposition for thigh control of film thickness
  • 99.99% pure silver
  • Optional titanium adhesion layer
  • Custom silver coated products are available

Applications include:

  • Surface Plasmon Resonance (SPR)
  • Self-Assembled Monolayers (SAMs)
  • High Reflectivity Mirrors
  • Atomic Force Microscopy
  • Electrochemistry
  • High Performance Printed Electrodes
  • Sensor and Biosensors


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G-Biosciences – Wild Type Purified Membrane Proteins

Wild type purified membrane proteins are isolated by patented technology that allows for the isolation in solution of full length and pure to highly pure membrane proteins.  These include GPCRs, ion channels, transporters, receptors and viral proteins.  These purified membrane proteins retain their structural and functional integrity and purification does not utilize refolding steps or mutagenesis.

 

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Micronic Screw Cap Recapper CS500, CS510, and CS520

Developed in conjunction with several leading laboratories, these Screw Cap Recappers offer the ability to cap, decap or recap a row of tubes in less than 5 seconds and a whole rack in only 1 minute.  This is 10 times faster than by hand and it helps to improves productivity.

  • Cost-effective solution
  • Each screw cap is reproducibly tightened securely and uniformly for an optimal sealing performance
  • Cycle time: caps a row of 8, 6 or 4 tubes in 4 seconds and a whole rack of 96, 48 or 24 tubes within 45-60 seconds
  • No need for battery recharging, available to use once plugged in

 

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EpiCypher - EpiTriton™ Histone Peptide Array

Designed for rapid and high-throughput screening of effector protein, antibody and enzyme interactions with a comprehensive library of combinatorially-modified and biotinylated histone peptides immobilized on a streptavidin-coated glass slide. The peptides encompass over 296 unique modifications on the four core histones (H2A, H2B, H3 and H4) and several histone variants.  Every Array contains more than 292 histone peptides spotted 12 times each for high quality detection and analysis of antibody or protein binding or enzyme activity.

  • Examine the selectivity and specificity of histone modification antibodies
  • Analyze the specificity of histone binding proteins
  • Identify substrates for histone-modifying enzymes

 

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Heathrow Scientific – Mini Vortexer

  • Made from durable ABS and silicone materials to resist most commonly used chemicals
  • Can be used with tubes ranging from 2 mL to 50 mL
  • Low profile design and small footprint (only 4.3” wide) save valuable space on a bench top and in fume hoods
  • Rapid vortex action saves time and enables quick mixing of samples
  • Easy one-handed touch start operation and shaking stops when the tube is lifted
  • Maintenance free design and 3 year warranty help reduce the cost of ownership
  • Quiet operation and low vibration on the vortex machine helps users stay focused

 

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Micronic – Hybrid Coded Tubes with External Thread

A versatile and unique combination of 4 codes on one tube:

  1. White blank surface to write your own sample info
  2. Numeric human-readable on the tube side wall
  3. 1D Barcode on the tube side wall
  4. 2D Data-Matrix code on the tube bottom

 

  • White bottom and side walls cannot be separated from the transparent tube due to a unique injection molding technique
  • 1D, 2D and human-readable codes are permanently laser-etched into the white surfaces
  • Triple start thread for optimal sealing quality
  • Improved sample integrity due to external thread (cross-contamination is minimized)
  • Thick tube walls and sturdy design for storage in ultra-low temperatures
  • Code surface has a raised edge to protect the 2D code
  • Produced in certified class-7 clean rooms

 

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Mirus Bio – TransIT® Lentivirus System

The TransIT® Lentivirus System combines the novel technologies of the TransIT®-Lenti Transfection Reagent with the Lentivirus Packaging Mix Powered by MISSION®. Titers of 108 can be achieved with an optimized protocol.

  • Produce 2-3x higher functional titers than Lipofectamine® 2000 & 3000
  • Achieve even higher titers and eliminate the need to concentrate
  • No media change required, single harvest

 

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Hycult Biotech - Alternative Complement Pathway Mouse and Pig ELISAs

  • Measures the alternative pathway activity mediated via LPS
  • Complement deficiencies or other defects in the complement system can easily be screened by running an assay for each pathway in parallel or separately
  • Contains a positive control* which can be used as control to ensure that the alternative complement cascade has run completely

 

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*This positive control cannot be used to determine the level of activation between batches. Hycult Biotech advises to include your own reference sample for 100% complement activity and negative control to determine the level of activation of your samples. Beware that complement activity levels are strain dependent and might be affected by the way the samples are collected and processed.

Heathrow – Dual Purpose Lab Scoop

  • A unique economical solution that combines the function of a scoop and a weigh boat into one product
  • Made from anti-static polystyrene that is waterproof and reduces the chance of materials sticking to the scoop
  • Ships and stores flat and when ready to use, is easy to assemble by inserting the locking tab into the hole

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NuGEN – Celero™ DNA-Seq Library System

  Celero™ DNA-Seq is an innovative library system designed to help researchers streamline library preparation for Illumina sequencers. Celero™ features a fast, easy-to-use, addition-only workflow that eliminates post-ligation bead purification. Also included is NuGEN's breakthrough quantitation method, NuQuant™, that saves both time and cost in measuring library concentration for pooling. With the proven DimerFree technology you can use from 10 ng to 1 μg of intact DNA and greater than 200 ng of FFPE DNA with a single kit without the worry of GC bias.

  • Faster library prep with reduced hands-on time: No adaptor or template dilution and no post- ligation purification
  • One kit, two workflows: PCR and PCR-free can be performed with the same kit, providing flexibility and reducing the number of kits that need to be purchased and stored
  • Simplified library pooling: NuQuant provides molarity without the need for costly and time-consuming methods

 

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Biosensing Instrument – SPRm 200 Surface Plasmon Resonance Microscopy System

Simultaneous optical imaging with SPR measurements.

The Surface Plasmon Resonance Microscopy (SPRM) system integrates optical microscopy and SPR to offer a powerful technique for measuring the binding activities of membrane proteins in vitro.  It allows the simultaneous measurement of phenotypical changes of the sample via bright field and binding strength and kinetics via SPR.

  • Integrated optical microscopy with SPR Bright-field and SPR microscopy in one instrument. Large field of view with high resolution optics to view single or multiple cells
  • In vitro and label-free binding activities mapping Provides SPR sensorgrams and binding activity map of individual cells as well as the binding kinetic constants (ka, kd, KD)
  • Nanometer scaled binding response of virus, bacteria and nanoparticles Nanomotion detection study of bacteria or virus metabolic activity or binding activities of nanoparticles for drug delivery designs

 

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Hycult Biotech - Proteinase 3 and sCD59 ELISA Kits

Proteinase 3: only for ANCA-associated vasculitis?

The Proteinase 3 enzyme, also known as PRTN3 or PR3, is a serine protease that is mainly expressed by neutrophil granulocytes.

Studies in the eighties and nineties already suggest an interaction between PR3 and emphysema, but also with an enhanced platelet response. A recent study underlines that PR3 is one of the key regulators in Wegener granulomatosis (GPA), which is one of the variants of ANCA-associated vasculitis. Besides inducing other auto-immune diseases such as rheumatoid arthritis and glomerulonephritis, a 2017 study established that the interaction between PR3 and RAGE (a cell surface receptor expressed on malignant cells) mediates homing and metastasis of prostate cancer cells to the bone marrow.

Even though a majority of studies using PR3 are historically related to vasculitis, there is an unprecedented number of autoimmune diseases and interactions within tumor immunology where the role of PR3 still has to be determined.

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sCD59: from inflammation to transplantation.

CD59, also known as the MAC-inhibitory protein, is a complement regulatory glycoprotein that inhibits membrane attack complex formation by preventing C9 from polymerizing. The soluble form of CD59 can be detected in a variety of body fluids and is associated with a range of different conditions. A paper from 1995 for example describes the role of CD59 in glomerulonephritis and in that same year there was a paper discussing the therapeutic potential of CD59 in inflammatory diseases.

Historically there have also been scientific articles specifying the role of this protein in relation to myocardial infarction, carcinoma, PNH and macular degeneration. The glycated form of CD59 also shows to be a useful marker for diabetes. Recent insights have further demonstrated that the soluble form of CD59 plays an important role in allograft rejection after transplantation. All these findings combined confirm that CD59 is a versatile regulatory protein that will remain a relevant target for scientific exploration of complement-mediated conditions.

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Labnet - C0336 and C0336R High Performance Centrifuges

These high performance centrifuges are capable of high speed operation, expanding their use to applications in molecular biology and basic research.

  • Max Speed:90 - 18,000 rpm, step 1 RPM
  • Max RCF: 24,270 x g, step 1 x g
  • Max Volume:500 mL
  • Temperature Range (C0336R):-20C to +40C, step 1C
  • Maintenance-free induction motor
  • 100 user programs
  • Continuous and short time operation modes
  • Programming of multi-segment acceleration and deceleration characteristics
  • Password protection

 

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