Mirus – Label IT® MFP488 Nucleic Acid Labeling Reagent
MFP488 provides a more robust option for nucleic acid labeling than traditional fluorescein methods.
- High Photostability – Facilitates longer time for observation and image capture
- Widespread Instrument Compatibility – Spectrally similar to fluorescein
- Stable at Low pH – Fluorescence is maintained over a broad range (pH 4-9)
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Click Image to Enlarge: Label IT® MFP488 Labeled Plasmid DNA is More Resistant to the Effects of Low pH as Compared to Label IT® Fluorescein Labeled Plasmid DNA. Plasmid DNA was labeled at a low density, 1 label per 65 bp, using Label IT® MFP488 or Label IT® Fluorescein Nucleic Acid Labeling Kits. Purified DNA was subsequently diluted in various pH buffers (50 mM HEPES, pH 8, 100 mM MES, pH 5.4, and 100 mM MES, pH 3). Fluorescence was measured using a Tecan Genios Fluorometer and normalized to the respective control measured at 50 mM HEPES, pH 8.